Key result
Dobutamine infusion increased the slope of the end-systolic pressure-dimension relation by 25% and the pressure-volume relation by 55% (both p<0.001) in normal subjects.
Why the study?
Does dobutamine infusion alter the slope of end-systolic pressure-dimension and pressure-volume relations in normal subjects?
Population
10 normal subjects
Comparison
Infusion of methoxamine to alter end-systolic… vs Baseline state prior to positive inotropic…
Design
Other
Authors
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End-systolic relations may sensitively track inotropy in normals; leaves open validation in larger cohorts or disease states.
Does dobutamine infusion alter the slope of end-systolic pressure-dimension and pressure-volume relations in normal subjects?
Effect estimate: 25% increase in pressure-dimension slope; 55% increase in pressure-volume slope
p-value: p=<0.001
The slopes of end-systolic pressure-dimension and pressure-volume relations are highly sensitive indicators of changes in left ventricular inotropic state in humans.
Borow et al. (1982) studied Normal subjects (n=10). Dobutamine and methoxamine infusion vs. Baseline was evaluated on Slope of the end-systolic pressure-dimension and pressure-volume relations (25% increase in pressure-dimension slope; 55% increase in pressure-volume slope, p=<0.001). Dobutamine infusion increased the slope of the end-systolic pressure-dimension relation by 25% and the pressure-volume relation by 55% (both p<0.001) in normal subjects.
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