April 1, 2008Critical Care Medicine
Multicenter, randomized, controlled trials evaluating mortality in intensive care: Doomed to fail?
Why the study?
What proportion of multicenter randomized controlled trials in adult intensive care units demonstrate a beneficial impact on mortality?
Population
72 adult, multicenter randomized controlled trials carried out in the intensive care unit, with mortality as…
Comparison
Various intensive care interventions vs Various control groups
Design
Systematic_review
Authors
Discussion
Loading...
Member takes
Implication
Most multicenter ICU RCTs show neutral mortality effects; challenges reliance on mortality endpoints and supports alternative primary outcomes in future trials.
Structured PICO
What proportion of multicenter randomized controlled trials in adult intensive care units demonstrate a beneficial impact on mortality?
P
Population
72 adult, multicenter randomized controlled trials carried out in the intensive care unit, with mortality as a primary outcome, and including >50 patients
I
Intervention
Various intensive care interventions
C
Comparator
Various control groups
O
Outcome
Mortalityhard clinical
Relatively few multicenter RCTs in the ICU setting demonstrate a beneficial impact on mortality, suggesting that other endpoints should be considered.
Limitations
- Methodological limitations of some of the randomized controlled trials may have prevented positive results
Cite This Study
Ospina‐Tascón et al. (2008) studied this question.