Key result
Hemodynamic optimization using monitoring combined with a structured algorithm did not significantly reduce mortality compared to standard of care in adult critically ill patients (OR 0.94).
Why the study?
Does protocolized hemodynamic goal-directed resuscitation reduce mortality in adult critically ill patients?
Meta-Analysis (n=3,323)
Does protocolized hemodynamic goal-directed resuscitation reduce mortality in adult critically ill patients?
Odds Ratio: 0.94 (95% CI 0.73–1.22)
Absolute Event Rate: 22.4% vs 22.9%
Protocolized hemodynamic goal-directed resuscitation does not significantly reduce mortality in adult critically ill patients compared to standard care.
No takes yet. Share an insight, caveat, or question.
No mortality benefit from protocolized hemodynamic optimization; insufficient high-quality trials leave benefit unproven.
Cronhjort et al. (2017) conducted a meta-analysis in Critical illness (n=3,323). Hemodynamic goal-directed resuscitation vs. Standard of care without structured hemodynamic intervention was evaluated on All-cause mortality (OR 0.94, 95% CI 0.73-1.22). Hemodynamic optimization using monitoring combined with a structured algorithm did not significantly reduce mortality compared to standard of care in adult critically ill patients (OR 0.94).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: