Key result
Intravenous administration of 10 mg verapamil significantly prolonged the AH interval from 99 to 150 msec and increased the effective and functional refractory periods of the AV node.
Why the study?
Does intravenous verapamil alter electrophysiological properties in a concentration-dependent manner in patients with paroxysmal supraventricular tachycardia?
Population
8 patients with a history of recurrent paroxysmal supraventricular tachycardia, mean age 57.1 years, mean…
Comparison
Verapamil 10 mg administered intravenously, with… vs Pretreatment control period.
Design
Case_series
Follow-up
120 minutes for electrophysiological studies and 8 hours…
Authors
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Supports concentration-dependent AV nodal effects in PSVT; leaves open validation in controlled trials.
Observational (n=8)
No
Does intravenous verapamil alter electrophysiological properties in a concentration-dependent manner in patients with paroxysmal supraventricular tachycardia?
Absolute Event Rate: 150% vs 99%
p-value: p=<0.01
Intravenous verapamil prolongs AV nodal conduction and refractoriness in a concentration-dependent manner, providing a pharmacokinetic and electrophysiological basis for its efficacy in terminating paroxysmal supraventricular tachycardia.
Koike et al. (1983) conducted an observational in Paroxysmal supraventricular tachycardia (n=8). Verapamil vs. Pretreatment baseline was evaluated on AH interval at 15 minutes (p=<0.01). Intravenous administration of 10 mg verapamil significantly prolonged the AH interval from 99 to 150 msec and increased the effective and functional refractory periods of the AV node.
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