Key result
Type 2 diabetes was associated with similar cardiac angiogenesis evaluated by 68 Ga-RGD PET compared to non-diabetic controls (TBR mean 0.89 vs 0.89; p=0.92).
Why the study?
The study was conducted to assess cardiac angiogenesis in type 2 diabetes using 68Ga-RGD PET imaging.
Does cardiac angiogenesis measured by 68Ga-RGD PET differ between persons with and without type 2 diabetes?
Cross-Sectional (n=30)
Does cardiac angiogenesis measured by 68Ga-RGD PET differ between persons with and without type 2 diabetes?
Absolute Event Rate: 0.89% vs 0.89%
p-value: p=0.92
Cardiac angiogenesis evaluated with 68Ga-RGD PET does not significantly differ between patients with type 2 diabetes and non-diabetic controls.
Preserved cardiac angiogenesis by 68Ga-RGD PET in type 2 diabetes warrants no clinical action; leaves open its relevance to microvascular dysfunction.
Aims To assess cardiac angiogenesis in type 2 diabetes by positron emission tomography (PET) tracer [ 68 Ga]Ga‐NODAGA‐E[(cRGDyK)] 2 ( 68 Ga‐RGD) imaging. Methods Cross‐sectional study including 20 persons with type 2 diabetes and 10 non‐diabetic controls (CONs). Primary prespecified outcome was difference in cardiac angiogenesis (cardiac 68 Ga‐RGD mean target‐to‐background ratio [TBR mean ]) between type 2 diabetes and CONs. Secondary outcome was to investigate associations between cardiac angiogenesis and kidney function and other risk factors. Results Participants with type 2 diabetes had a mean ± SD age of 61 ± 9 years, 30% were women, median (IQR) diabetes duration of 11 (6–19) years and 3 (15%) had a history of cardiovascular disease. The CONs had comparable age and sex distribution to the participants with type 2 diabetes, and none had a history of coronary artery disease. Myocardial flow reserve was lower in type 2 diabetes (2.7 ± 0.6) compared with CONs (3.4 ± 1.2) ( p = 0.03) and coronary artery calcium score was higher (562 [142–905] vs. 1 [0–150] p = 0.04). Cardiac 68 Ga‐RGD TBR mean was similar in participants with type 2 diabetes (0.89 ± 0.09) and CONs (0.89 ± 0.10) ( p = 0.92). Cardiac 68 Ga‐RGD TBR mean was not associated with estimated glomerular filtration rate, urine albumin creatinine ratio, cardiovascular disease, coronary artery calcium score or baroreflex sensitivity, neither in pooled analyses nor in type 2 diabetes. Conclusions Cardiac angiogenesis, evaluated with 68 Ga‐RGD PET, was similar in type 2 diabetes and CONs. Cardiac angiogenesis was not associated with kidney function or other risk markers in pooled analyses or in analyses restricted to type 2 diabetes.
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Laursen et al. (2022) conducted a cross-sectional in Type 2 diabetes (n=30). Type 2 diabetes vs. Non-diabetic controls was evaluated on Cardiac angiogenesis (cardiac 68 Ga-RGD mean target-to-background ratio [TBR mean]) (p=0.92). Type 2 diabetes was associated with similar cardiac angiogenesis evaluated by 68 Ga-RGD PET compared to non-diabetic controls (TBR mean 0.89 vs 0.89; p=0.92).
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