Key result
Higher long-term visit-to-visit systolic blood pressure variability was independently associated with an increased risk of incident diabetes mellitus (HR 1.60 for highest vs lowest quartile).
Why the study?
To examine the association between visit-to-visit blood pressure variability and incident diabetes mellitus risk in a Chinese population.
Does high visit-to-visit blood pressure variability increase the risk of incident diabetes mellitus in a Chinese population?
Cohort (n=15,084)
Yes
Does high visit-to-visit blood pressure variability increase the risk of incident diabetes mellitus in a Chinese population?
Hazard Ratio: 1.6 (95% CI 1.3–1.97)
Absolute Event Rate: 6.09% vs 3.07%
p-value: p=<0.01
Higher long-term visit-to-visit systolic and diastolic blood pressure variability is independently associated with an increased risk of incident diabetes mellitus.
BP variability associated with diabetes risk; hypothesis-generating and requires prospective trials before clinical consideration.
Objectives: To examine the association between visit-to-visit blood pressure variability (BPV) and incident diabetes mellitus (DM) risk in a Chinese population. Methods: Data comes from China Health and Nutrition Survey ( n = 15,084). BPV was estimated as the average real variability (ARV) using at least three BP measurements from the year preceding the event and was divided into quartiles. Participants were also categorized into 9 groups on the basis of combinations of systolic BPV (SBPV) and diastolic BPV (DBPV) tertiles. Cox proportional hazards regression models were used. Results: During a median follow-up of 16.8 years, 1,030 (6.8%) participants developed diabetes (incidence rate: 4.65/1,000 person-years). The HRs (95% CIs) for the highest quartile (vs. the lowest quartile) of SBPV and DBPV were 1.60 (1.30–1.97) and 1.37 (1.13–1.67), respectively. Participants with both highest SBPV and DBPV tertile had an ≈89% higher risk of DM (HR, 1.89; 95% CI, 1.47–2.42) compared with those in the both SBPV and DBPV tertile 1 group. Conclusion: Higher SBP ARV and DBP ARV were independently associated with increased risk of incident DM, which was augmented when both presented together.
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Zhou et al. (2023) conducted a cohort in Diabetes Mellitus (n=15,084). High visit-to-visit blood pressure variability (SBPV) vs. Low visit-to-visit blood pressure variability (lowest quartile) was evaluated on Incident diabetes mellitus (HR 1.60, 95% CI 1.30-1.97, p=<0.01). Higher long-term visit-to-visit systolic blood pressure variability was independently associated with an increased risk of incident diabetes mellitus (HR 1.60 for highest vs lowest quartile).
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