Key result
Gut microbiome and TMAO appear to influence cardiac arrhythmias via autonomic, inflammatory, and metabolic pathways.
Why the study?
The relationship between the gut microbiome and human health is increasingly recognized, prompting a need to understand the pathways and intermediaries mediating interactions between the gut microbiome and cardiac arrhythmias.
This review highlights the emerging role of the gut microbiome in the pathogenesis of cardiac arrhythmias via autonomic, inflammatory, and metabolic pathways, suggesting potential novel therapeutic targets.
Does not support microbiome interventions for arrhythmias; leaves open mechanistic pathways for prospective trials.
Background: The relationship between the gut microbiome and overall human health is increasingly recognized. This review discusses new research that outlines pathways and intermediaries that may mediate the interaction between the gut microbiome and cardiac arrhythmias. Observations: Gut microbial constituents and their products have been shown to influence human physiology, including the cardiovascular system, cardiac arrhythmia, and other disease processes. The effect of the human gut microbiome on cardiovascular diseases may improve understanding of disease pathophysiologic mechanisms and presents opportunities for therapeutic modification of the gut microbiome to positively affect disease outcomes. Conclusions: Research into the gut microbiome and its overarching impact on the human body is still in its early stages. Continued investigation of its complex relationships may lead to the development of novel therapies and strategies to enhance patient safety.
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R. Ashton Vautier (2025) conducted a review in Cardiac Arrhythmias. Gut microbiome was evaluated. The gut microbiome and its metabolites, such as TMAO and short-chain fatty acids, appear to influence the development of cardiac arrhythmias through autonomic, inflammatory, and metabolic pathways.
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