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April 11, 2025International Journal of Biological and Pharmaceutical Sciences ArchiveOpen Access

Gut microbiome influences cardiovascular health via TMAO and SCFAs, highlighting potential for microbiome-targeted therapies.

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Why the study?

The gut microbiome influences cardiovascular disease pathophysiology, but clinical translation and standardized microbiome-based therapies remain challenging.

Design

Review of gut microbiome influence on cardiovascular health

Key result

The gut microbiome significantly influences cardiovascular health through microbial metabolites like TMAO and SCFAs, highlighting the potential of microbiome-targeted therapies for cardiovascular disease.

Authors

SDSanat Mahendra Dhoke

Discussion

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Overview

Does not yet support microbiome-targeted therapies in routine care; leaves open their efficacy pending randomized trials.

PICO

P
Population
Cardiovascular disease
I
Intervention / Comparator
Microbiome-targeted therapies

The gut microbiome and its metabolites significantly influence cardiovascular disease pathophysiology, presenting a potential target for future customized microbiome-based therapies.

Limitations

  • Heterogeneity in gut microbiome composition
  • Limitations in microbiome research methodologies
  • Challenges in clinical translation of microbiome-based therapies
  • Need for large-scale, longitudinal studies
  • Ethnic and regional variability in microbiome-CVD interactions
  • Differences in gut microbiota makeup
  • Difficulties with clinical translation
  • Requirement for standardized procedures

Cite This Study

Sanat Mahendra Dhoke (2025) conducted a review in Cardiovascular disease. Microbiome-targeted therapies was evaluated. The gut microbiome significantly influences cardiovascular health through microbial metabolites like TMAO and SCFAs, highlighting the potential of microbiome-targeted therapies for cardiovascular disease.

synapsesocial.com/papers/6aad04d2bb7b6cc8e7d21950https://doi.org/10.53771/ijbpsa.2025.9.2.0034
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gut Microbiota and Its Implications for Cardiovascular Diseases – a Review2024 · 3 citations
  2. 2The Gut–Heart Axis: A Comprehensive Review of Microbiota’s Role in Cardiovascular Health and Disease and Emerging Therapeutic Strategies2026 · 10 citations
  3. 3Exploring the significance of gut microbiota in cardiovascular health2025 · 1 citations
  4. 4The gut-heart axis: Exploring the role of the gut microbiome in cardiovascular health – A focused systematic review2025 · 3 citations
  5. 5Emerging therapy targets to modulate microbiome-mediated effects evident in cardiovascular disease2025 · 5 citations