Why the study?
The review examines the role of the gut microbiota in cardiovascular disease, exploring mechanisms linking gut dysbiosis to CVD and evaluating microbiome-targeted interventions.
Do microbiome-targeted interventions improve cardiovascular risk factors and outcomes in cardiovascular disease?
Population
Nine eligible studies evaluating gut microbiota in CVD
Comparison
Dietary modifications, probiotics, prebiotics, fecal microbiota transplantation, and pharmacological agents vs unstated comparators
Design
Focused systematic review
Key result
Probiotic strains and fiber-rich diets demonstrated modest improvements in blood pressure, lipid profiles, and inflammatory markers in cardiovascular disease.
Authors
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Supports further microbiome-targeted research in CVD; too preliminary and heterogeneous for clinical adoption.
Systematic Review
Do microbiome-targeted interventions improve cardiovascular risk factors and outcomes in cardiovascular disease?
Modulation of the gut microbiome via diet and probiotics shows modest potential for improving cardiovascular risk factors, but current evidence remains early and exploratory.
Makkieh et al. (2025) conducted a systematic review in Cardiovascular disease. Gut microbiome modulation (dietary modifications, probiotics, prebiotics, FMT, pharmacological agents) was evaluated. Probiotic strains and fiber-rich diets demonstrated modest improvements in blood pressure, lipid profiles, and inflammatory markers in cardiovascular disease.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: