Key result
Emax in canine left ventricles fell from 2.06 to 1.38 kPa/ml via sino-aortic baroreceptor reflex, rose to 3.83 kPa/ml with cerebral ischaemia, and fell to 1.17 kPa/ml after cardiac denervation.
Why the study?
How do physiological reflexes and denervation affect ventricular contractility as assessed by Emax in canine left ventricles?
Population
Canine left ventricles
Comparison
Physiological manipulations vs Baseline state
Design
Preclinical
Authors
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Emax sensitively tracks autonomic modulation of contractility in canines; leaves open translation to human indices and clinical use.
How do physiological reflexes and denervation affect ventricular contractility as assessed by Emax in canine left ventricles?
Emax is a responsive index of ventricular contractility that appropriately reflects changes induced by autonomic reflexes and denervation in a canine model.
Suga et al. (1976) studied this question. Sino-aortic baroreceptor reflex, cerebral ischaemia, and cardiac denervation vs. Baseline was evaluated on Emax (pressure-volume ratio). Emax in canine left ventricles fell from 2.06 to 1.38 kPa/ml via sino-aortic baroreceptor reflex, rose to 3.83 kPa/ml with cerebral ischaemia, and fell to 1.17 kPa/ml after cardiac denervation.
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