Key result
A proposed dynein cross-bridge cycle incorporating an anchored head and a ratchet-like mechanism for microtubule translocation by the B-link may reconcile dynein oscillation and interdoublet sliding.
Theoretical analysis suggests that dynein's globular head requires additional stabilization during the power stroke, proposing a ratchet-like mechanism for microtubule translocation.
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Proposed dynein cycle is hypothesis-generating; leaves open experimental validation and extension to ciliary motility disorders.
Lindemann et al. (2003) studied this question. A proposed dynein cross-bridge cycle incorporating an anchored head and a ratchet-like mechanism for microtubule translocation by the B-link may reconcile dynein oscillation and interdoublet sliding.
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