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November 1, 1979Proceedings of the National Academy of SciencesOpen Access

Dynein binds to and crossbridges cytoplasmic microtubules.

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Population

In vitro model using dynein isolated from Chlamydomonas flagellar axonemes and microtubules assembled from…

Design

Preclinical

Authors

LHLeah T. HaimoUniversity of California, RiversideBTB R TelzerMarine Biological LaboratoryJRJoel L. RosenbaumThe Ohio State University

Discussion

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Implication

Supports dynein-microtubule crossbridging in motility models; leaves open relevance to cardiovascular cytoskeletal dynamics.

Structured PICO

P
Population
In vitro model using dynein isolated from Chlamydomonas flagellar axonemes and microtubules assembled from 6S brain tubulin dimers
I
Intervention
Addition of dynein to microtubules and subsequent addition of ATP
O
Outcome
Binding characteristics, periodicity, crossbridging, and effect of ATP on microtubule aggregationsurrogate

Dynein binds to and crossbridges cytoplasmic microtubules, an interaction that is reversed by ATP, suggesting a role in microtubule-based cellular movements.

Cite This Study

Haimo et al. (1979) studied this question.

synapsesocial.com/papers/6a830ae586395db871b381bdhttps://doi.org/10.1073/pnas.76.11.5759
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Also Consider

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  1. 1STUDIES ON CILIA1968 · 567 citations
  2. 2Chromosome movement in lysed mitotic cells is inhibited by vanadate.1978 · 154 citations
  3. 3Cell cycle-dependent, in vitro assembly of microtubules onto pericentriolar material of HeLa cells.1979 · 94 citations
  4. 4Binding of 30s Dynein with the B-Tubule of the Outer Doublet of Axonemes from Tetrahymena pyriformis and Adenosine Triphosphate-Induced Dissociation of the Complex11978 · 104 citations
  5. 5The periodic association of MAP2 with brain microtubules in vitro.1979 · 510 citations