Key result
Novel LV simulator uses personalized elastance to recreate physiological and pathological hemodynamics for device testing.
Why the study?
Mechanical models testing mechanical circulatory systems and interventional cardiac devices in vitro must recreate the physiological hemodynamics present inside the human body.
The development of an elastance-controlled left ventricle simulator provides a novel in vitro test platform for validating mechanical circulatory systems and interventional cardiac devices under varying physiological and pathological conditions.
Mechanical models of the human cardiovascular system exist as test platforms to study the performance of mechanical circulatory systems (MCSs) and interventional cardiac devices in vitro, and they must recreate the physiological hemodynamics that would be present inside the human body. This work describes a left ventricle simulator (LVS) that implements a personalized elastance model to control ventricular contraction via a linear motor-driven piston, simulating variable physiological and pathological conditions. The system simulated ventricular and aortic hemodynamics, the Frank-Starling autoregulatory mechanism, atrial kick, and physiological pulsatile flow at varying heart rates for both healthy heart and heart failure conditions. Elastance control not only provides precise motor actuation, but also allows for the simulation of specific heart function, and this work ultimately introduces a novel test platform for heart device validation.
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Peak et al. (2023) studied this question. Left ventricle simulator (LVS) with personalized elastance model was evaluated on Simulation of ventricular and aortic hemodynamics, Frank-Starling mechanism, atrial kick, and pulsatile flow. A novel left ventricle simulator successfully implemented a personalized elastance model to recreate physiological and pathological hemodynamics for testing mechanical circulatory systems.
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