Key result
Tailored pacemaker rate-response programming limiting heart rate rise below the critical HR increased exercise time compared to conventional programming (475 vs 425 s; p=0.003).
Why the study?
Does tailored pacemaker rate-response programming based on the force-frequency relationship improve exercise time and maximal oxygen consumption in patients with chronic heart failure and pacemakers?
RCT (n=52)
Double-blind
Randomized crossover
Does tailored pacemaker rate-response programming based on the force-frequency relationship improve exercise time and maximal oxygen consumption in patients with chronic heart failure and pacemakers?
Absolute Event Rate: 475% vs 425%
p-value: p=0.003
Personalized pacemaker rate-response programming based on the noninvasively assessed force-frequency relationship significantly improves exercise time and peak oxygen consumption in patients with chronic heart failure.
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Supports tailored rate-response programming to improve exercise capacity in paced HF patients; extends force-frequency evidence in RCT.
Gierula et al. (2017) conducted an RCT in Chronic heart failure (n=52). Tailored pacemaker rate-response programming vs. Conventional rate-response programming was evaluated on Exercise time (seconds) (p=0.003). Tailored pacemaker rate-response programming limiting heart rate rise below the critical HR increased exercise time compared to conventional programming (475 vs 425 s; p=0.003).
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