Key result
SARS-CoV-2 infection causes diverse cardiovascular complications linked to higher mortality, especially with pre-existing CVD.
Why the study?
COVID-19 has severe implications in the cardiovascular system, requiring an integration of clinical observations and experimental findings to understand underlying mechanisms and aid in identifying and treating cardiovascular injury.
COVID-19 has severe bidirectional implications with the cardiovascular system, necessitating cardiac monitoring and continued guideline-directed medical therapy during infection.
Answers are grounded in this paper and cite their sources.
Warrants cardiac monitoring in COVID-19 patients with pre-existing CVD; leaves open optimal interventions pending prospective trials.
The coronavirus disease 2019 (COVID-19) remains a global public health emergency. Despite being caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), besides the lung, this infectious disease also has severe implications in the cardiovascular system. In this review, we summarize diverse clinical complications of the heart and vascular system, as well as the relevant high mortality, in COVID-19 patients. Systemic inflammation and angiotensin-converting enzyme 2-involved signaling networking in SARS-CoV-2 infection and the cardiovascular system may contribute to the manifestations of cardiovascular diseases. Therefore, integration of clinical observations and experimental findings can promote our understanding of the underlying mechanisms, which would aid in identifying and treating cardiovascular injury in patients with COVID-19 appropriately.
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Liu et al. (2020) conducted a review in COVID-19 and cardiovascular diseases. SARS-CoV-2 infection was evaluated. SARS-CoV-2 infection causes diverse cardiovascular complications, including myocardial injury, arrhythmias, and heart failure, which are associated with high mortality, especially in those with pre-existing cardiovascular disease.
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