Key result
Blood volume expansion in conscious areflexic rats increased vascular resistance by 15% in the whole body, 8% in the intestine, 18% in the kidney, and 15% in the hind limb.
Why the study?
Does blood volume expansion induce regional vascular autoregulation in conscious areflexic rats?
Population
Conscious areflexic rats (n=7 for superior mesenteric, n=7 for left renal, n=7 for right iliac arteries)
Comparison
Blood volume expansion with infusion of 0.9 ml… vs Resting control values and whole body…
Design
Preclinical
Follow-up
6 minutes
Authors
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Does not alter clinical volume management; leaves open regional autoregulation mechanisms in hypertension models.
Does blood volume expansion induce regional vascular autoregulation in conscious areflexic rats?
In conscious areflexic rats, blood flow autoregulation during volume expansion varies by vascular bed, being greater in the kidney and lesser in the intestine compared to the whole body.
Hinojosa‐Laborde et al. (1991) studied Conscious areflexic rats. Blood volume expansion vs. Resting control values was evaluated on Vascular resistance and pressure-flow slope. Blood volume expansion in conscious areflexic rats increased vascular resistance by 15% in the whole body, 8% in the intestine, 18% in the kidney, and 15% in the hind limb.
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