Key result
Experimental congestive heart failure in rats was associated with significantly higher cyclic renal sympathetic nerve activity compared with sham-operated controls (47% vs 34%, P<0.005).
Why the study?
Does experimental congestive heart failure alter renal sympathetic nerve activity and its reflex control in rats?
Population
Rats with experimental congestive heart failure induced by left coronary artery ligation, and sham-operated…
Comparison
Experimental congestive heart failure vs Sham-operated rats subjected to thoracotomy
Design
Preclinical
Authors
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Heightened renal sympathetic activity in rat CHF models; leaves open translation to human HF mechanisms or therapies.
Does experimental congestive heart failure alter renal sympathetic nerve activity and its reflex control in rats?
Absolute Event Rate: 47% vs 34%
p-value: p=< 0.005
Experimental congestive heart failure in rats is associated with increased efferent renal sympathetic nerve activity and altered reflex control mechanisms.
Feng et al. (1994) studied Congestive heart failure. Experimental congestive heart failure vs. Sham-operated controls was evaluated on Neural cycle activity of the renal nerve (p=< 0.005). Experimental congestive heart failure in rats was associated with significantly higher cyclic renal sympathetic nerve activity compared with sham-operated controls (47% vs 34%, P<0.005).
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