Key result
Sinoaortic baroreceptor denervation did not exacerbate the development of hypertension in adult spontaneously hypertensive rats or lead to hypertension in Wistar-Kyoto rats.
Why the study?
Does sinoaortic baroreceptor denervation exacerbate hypertension in spontaneously hypertensive rats or cause hypertension in Wistar-Kyoto rats?
Does sinoaortic baroreceptor denervation exacerbate hypertension in spontaneously hypertensive rats or cause hypertension in Wistar-Kyoto rats?
Absolute Event Rate: 166% vs 163%
Baroreceptor denervation does not exacerbate or cause hypertension in spontaneously hypertensive or Wistar-Kyoto rats, indicating that primary baroreceptor reflex dysfunction alone does not drive hypertension in this model.
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Questions baroreflex impairment as hypertension initiator in rat models; leaves open its role in human disease.
John W. Osborn (1991) studied Hypertension. Sinoaortic baroreceptor denervation vs. Sham denervation was evaluated on Arterial pressure. Sinoaortic baroreceptor denervation did not exacerbate the development of hypertension in adult spontaneously hypertensive rats or lead to hypertension in Wistar-Kyoto rats.
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