Why the study?
Does acute sinoaortic denervation reveal differences in baroreceptor function between spontaneously hypertensive rats and normotensive rats?
Population
Spontaneously hypertensive rats and normotensive Wistar rats at 30-60 days and adult age
Comparison
Acute sinoaortic denervation vs Normotensive Wistar rats
Design
Preclinical
Follow-up
acute
Authors
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Does not support primary baroreceptor dysfunction in spontaneous hypertension; leaves open central vasomotor mechanisms for further study.
Does acute sinoaortic denervation reveal differences in baroreceptor function between spontaneously hypertensive rats and normotensive rats?
The findings suggest that primary baroreceptor dysfunction is not the cause of spontaneous hypertension, pointing instead to primary activation of the vasomotor center.
Thant et al. (1969) studied this question.
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