Key result
Rapidly activating I(Kr) provides a delayed voltage-dependent outward transient during ventricular repolarization, consistent with rapid recovery from inactivation.
Population
canine ventricular, atrial, and Purkinje myocytes
Comparison
voltage-clamp waveforms simulating the action… vs inward rectifier current (I(K1))
Design
Preclinical
Authors
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May inform repolarization models; leaves open I(Kr) contribution to human arrhythmias and drug effects.
The rapidly activating delayed rectifier current (IKr) provides a delayed voltage-dependent outward transient during ventricular repolarization, with heterogeneous voltage dependence that may modulate its contribution.
Gary A. Gintant (2000) studied this question. Voltage-clamp waveforms simulating the action potential vs. Inward rectifier current (I(K1)) was evaluated on Characterization of I(Kr) during ventricular repolarization. Rapidly activating I(Kr) provides a delayed voltage-dependent outward transient during ventricular repolarization, consistent with rapid recovery from inactivation.
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