August 1, 2001The Journal of PhysiologyOpen Access

Rate dependency of delayed rectifier currents during the guinea‐pig ventricular action potential

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Population

Guinea-pig ventricular myocytes

Comparison

Pacing at cycle lengths of 1000 and 250 ms… vs Different pacing conditions

Design

Preclinical

Authors

MRMarcella RocchettiUniversity of Milano-Bicocca ABAlessandra BesanaColumbia University Irving Medical Center GGGeorgina B. GurrolaUniversidad Autónoma del Estado de Morelos

Discussion

Member takes

Implication

May inform rate-dependent repolarization in long QT syndromes; leaves open human translation from animal data.

Structured PICO

Population

Guinea-pig ventricular myocytes

Intervention

Pacing at cycle lengths of 1000 and 250 ms, modulation of diastolic interval and action potential shape

Comparator

Different pacing conditions (e.g., varying cycle lengths, diastolic intervals, and action potential shapes)

Outcome

Rate dependency, activation, and magnitude of delayed rectifier currents (I(Kr) and I(Ks))surrogate

Both I(Kr) and I(Ks) currents increase at fast heart rates through distinct mechanisms, which may contribute to abnormal rate dependency of repolarization in prolonged repolarization syndromes.

Cite This Study

Rocchetti et al. (2001) studied this question.

synapsesocial.com/papers/6a70a54afebe604dd7096a5e https://doi.org/10.1111/j.1469-7793.2001.00721.x

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Rate dependency of delayed rectifier currents during the guinea‐pig ventricular action potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rate dependency of delayed rectifier currents during the guinea‐pig ventricular action potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider