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July 1, 1991Headache The Journal of Head and Face Pain

Autonomic Nervous System Function in Migraine Without Aura

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Key result

Migraine without aura was associated with non-specific sympathetic hyperactivity, but no impairment of autonomic cardiovascular control during headache-free intervals compared to controls.

Why the study?

Are there abnormalities in autonomic nervous system function in females with migraine without aura during headache-free intervals compared to controls?

Population

13 females with migraine without aura during headache-free intervals

Comparison

Physiological, pharmacological and biochemical… vs Controls

Design

Case-control

Authors

PCPietro CortelliUniversity of MessinaGPGiulia PierangeliIstituto delle Scienze Neurologiche di BolognaPPPiero ParchiGNA University

Discussion

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Implication

Hypothesis-generating for sympathetic hyperactivity in migraine; does not support altering autonomic cardiovascular assessment in practice.

Study Design

Type

Case-Control (n=13)

Structured PICO

Are there abnormalities in autonomic nervous system function in females with migraine without aura during headache-free intervals compared to controls?

P
Population
13 females with migraine without aura evaluated for autonomic nervous system functions during headache-free intervals compared to controls.
E
Exposure
Physiological, pharmacological and biochemical autonomic function tests (Valsalva manoeuvre, cold-face test, isometric handgrip, deep breathing, noradrenaline infusion, clonidine infusion)
C
Comparator
Controls
O
Outcome
Autonomic nervous system function (heart rate, blood pressure, and plasma noradrenaline responses)surrogate

Patients with migraine without aura exhibit non-specific sympathetic hyperactivity during headache-free intervals, but retain normal autonomic control of the cardiovascular system.

Cite This Study

Cortelli et al. (1991) conducted a case-control in Migraine without aura (n=13). Migraine without aura vs. Controls was evaluated on Autonomic nervous system functions (physiological, pharmacological and biochemical tests). Migraine without aura was associated with non-specific sympathetic hyperactivity, but no impairment of autonomic cardiovascular control during headache-free intervals compared to controls.

synapsesocial.com/papers/6a230a50d6da8eab4757feachttps://doi.org/10.1111/j.1526-4610.1991.hed3107457.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autonomic Dysfunction in Migraineurs1999 · 80 citations
  2. 2Power Spectral Analysis of Heart Rate and Diastolic Blood Pressure Variability in Migraine with and Without Aura1997 · 37 citations
  3. 3Autonomic Dysfunction in Migraine: A Survey of 188 Patients1988 · 59 citations
  4. 4Autonomic Dysfunction in Adult Migraineurs1986 · 54 citations
  5. 5Autonomic Function Testing in Patients with Migraine1993 · 81 citations