Key result
Pregnant ewes exhibited reduced gain of the cardiac baroreflex and attenuation of baroreceptor-mediated sympathetic effects on the heart compared with non-pregnant ewes.
Population
10 ewes (4 non-pregnant and 6 pregnant)
Comparison
Beta-adrenoreceptor blockade with propranolol… vs Before blockade; non-pregnant ewes
Design
Preclinical
Authors
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No immediate implications for pregnant patients; leaves open translation of ovine baroreflex attenuation to human pregnancy.
The study demonstrates a method using the MAP-HRV relationship to measure autonomic control of the heart, revealing that pregnancy in sheep attenuates baroreceptor-mediated sympathetic effects.
Lumbers et al. (1999) studied Pregnancy (n=10). Pregnancy vs. Non-pregnant state was evaluated on Cardiac baroreflex gain and MAP-HRV relationship. Pregnant ewes exhibited reduced gain of the cardiac baroreflex and attenuation of baroreceptor-mediated sympathetic effects on the heart compared with non-pregnant ewes.
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