Key result
Resting tension of intact frog atrial cells increased from ~10 nN at 2.35 microns to ~130 nN at 3.45 microns, indicating resting tension resides primarily in structures external to the cell.
Population
Single intact frog atrial cardiac cells
Design
Preclinical
Authors
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Single-cell data underestimate tissue resting tension; leaves open extracellular matrix contributions to diastolic stiffness in mammals.
The study demonstrates that the relatively high resting tension characteristic of cardiac tissue resides primarily in structures external to the individual cardiac cells.
Tarr et al. (1979) studied this question. Sarcomere length changes was evaluated on Resting tension (stress)-sarcomere length relationships. Resting tension of intact frog atrial cells increased from ~10 nN at 2.35 microns to ~130 nN at 3.45 microns, indicating resting tension resides primarily in structures external to the cell.
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