Key result
In isolated frog atrial trabeculae, sarcomere lengths varied with trabeculae diameter and increased with stretch, while A band width remained constant only between 2.3 and 2.6 micrometers.
Population
Isolated resting frog atrial trabeculae
Comparison
Application of passive tension (stretching) vs Absence of resting tension
Design
Preclinical
Authors
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Caution against extrapolating to human myocardium; extends sarcomere mechanics insights in amphibian models and leaves open mammalian validation.
This basic science study demonstrates that connective tissue is a major factor determining sarcomere length in resting frog atrial trabeculae.
Saul Winegrad (1974) studied this question. Stretch / passive tension vs. Absence of resting tension was evaluated on Sarcomere length and A band width. In isolated frog atrial trabeculae, sarcomere lengths varied with trabeculae diameter and increased with stretch, while A band width remained constant only between 2.3 and 2.6 micrometers.
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