Key result
Individual cardiac myofibrils develop the same average amount of active force and bear essentially the same passive force as single skeletal myofibrils.
Population
Isolated myofibrils and bundles of two to four myofibrils prepared from glycerinated tibialis anterior and…
Comparison
Force measurements at 15 degrees C and sarcomere… vs Comparison between cardiac and skeletal muscle…
Design
Preclinical
Authors
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Should not change clinical management of cardiac stiffness; leaves open whether non-myofibrillar elements drive stiffness in mammalian hearts.
Absolute Event Rate: 1.47% vs 0.45%
Individual cardiac myofibrils develop the same average amount of active force as single skeletal myofibrils, and structures other than myofibrils are responsible for the high passive stiffness of frog cardiac muscle.
Colomo et al. (1997) studied this question. Cardiac myofibrils (frog atrial myocytes) vs. Skeletal myofibrils was evaluated on Maximum active force. Individual cardiac myofibrils develop the same average amount of active force and bear essentially the same passive force as single skeletal myofibrils.
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