Key result
Imipramine (150 mg) increased supine systolic blood pressure and orthostatic heart rate, and induced pronounced orthostatic hypotension in 3 of 6 subjects during low sodium balance.
Why the study?
Does imipramine affect orthostatic changes in blood pressure, heart rate, and plasma catecholamines in healthy males?
Population
6 healthy male subjects
Comparison
150 mg imipramine hydrochloride ingestion vs Before ingestion (baseline)
Design
Other
Follow-up
2 hours
Authors
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Imipramine may induce orthostatic hypotension in low-sodium states; leaves open clinical relevance in patients.
Does imipramine affect orthostatic changes in blood pressure, heart rate, and plasma catecholamines in healthy males?
Imipramine induces orthostatic hypotension, particularly under conditions of low sodium balance, likely due to alpha 1-adrenoceptor blockade.
Nielsen et al. (1983) studied Healthy (n=6). Imipramine hydrochloride vs. Before ingestion (baseline) was evaluated on Orthostatic changes in heart rate, blood pressure and plasma catecholamines. Imipramine (150 mg) increased supine systolic blood pressure and orthostatic heart rate, and induced pronounced orthostatic hypotension in 3 of 6 subjects during low sodium balance.
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