Key result
Probucol treatment prevented increases in oxidative stress, inflammation, and matrix metalloproteinase activity and attenuated LV dysfunction and remodeling in tachycardia-induced heart failure.
Why the study?
Does probucol attenuate left ventricular dysfunction and remodeling in a canine model of tachycardia-induced heart failure?
Population
Dogs in a preclinical model of tachycardia-induced heart failure (ventricular pacing at 240 bpm)
Comparison
Probucol 100 mg/kg IP per week for 4 weeks vs Ventricular pacing at 240 bpm without probucol…
Design
Preclinical
Follow-up
4 weeks
Authors
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Does not support clinical use of probucol in HF; leaves open antioxidant strategies for remodeling in experimental models.
Does probucol attenuate left ventricular dysfunction and remodeling in a canine model of tachycardia-induced heart failure?
Probucol attenuates LV dysfunction and remodeling in a canine model of tachycardia-induced heart failure, suggesting a role for antioxidant and anti-inflammatory therapies.
Nakamura et al. (2002) studied Tachycardia-induced heart failure. Probucol vs. Ventricular pacing without probucol and sham-operated control was evaluated on Myocardial oxidative stress, inflammation, and left ventricular dysfunction and remodeling. Probucol treatment prevented increases in oxidative stress, inflammation, and matrix metalloproteinase activity and attenuated LV dysfunction and remodeling in tachycardia-induced heart failure.
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