Key result
Probucol decreased oxidative stress, attenuated collagen synthesis by inhibiting collagen mRNA expressions, and improved diastolic function in post-myocardial infarction rats.
Authors
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Probucol may benefit post-MI diastolic function; leaves open translation to patients pending human trials.
RCT
randomly assigned
Zhou et al. (2009) conducted an RCT in Post-myocardial infarction. Probucol vs. Vehicle was evaluated on Myocardial oxidative stress and collagen remodeling (including type I and III collagen and mRNA expressions). Probucol decreased oxidative stress, attenuated collagen synthesis by inhibiting collagen mRNA expressions, and improved diastolic function in post-myocardial infarction rats.
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