Key result
Probucol significantly decreased the left ventricle/body weight ratio and improved endothelium-dependent relaxations in a swine model of left ventricular hypertrophy.
Why the study?
Does probucol improve endothelial dysfunction and limit left ventricular hypertrophy in a swine model of aortic banding?
Population
Swine model of left ventricular hypertrophy (LVH) induced by aortic banding (AB)
Comparison
Probucol 1000 mg/d orally, administered starting… vs Untreated aortic banding group receiving…
Design
Preclinical
Follow-up
Up to 90 days
Authors
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Hypothesis-generating in swine LVH; leaves open translation to human endothelial function or hypertrophy.
Does probucol improve endothelial dysfunction and limit left ventricular hypertrophy in a swine model of aortic banding?
In a swine model of aortic banding, the antioxidant probucol limited the development and induced regression of left ventricular hypertrophy and associated coronary endothelial dysfunction.
Aubin et al. (2006) studied Left ventricular hypertrophy. Probucol vs. Placebo was evaluated on Left ventricle/body weight ratio and endothelium-dependent relaxations. Probucol significantly decreased the left ventricle/body weight ratio and improved endothelium-dependent relaxations in a swine model of left ventricular hypertrophy.
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