What question did this study set out to answer?

To evaluate the effects of long-term probucol administration on endothelial function and cardiovascular biomarkers in patients with coronary artery disease.

January 1, 2004Hypertension ResearchOpen Access

Long-Term Treatment with Probucol Improves Endothelial Function in Patients with Coronary Artery Disease

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Why the study?

Does probucol improve endothelial function in patients with coronary artery disease?

Population

38 patients total, comprising 26 patients with coronary artery disease and 12 controls without CAD. A subset…

Comparison

Probucol 500 mg/day for 3 months vs Placebo for 3 months

Follow-up

3 months

Authors

TTTatsuya TagawaFukuoka International University YUYoshitoshi UrabeYamagata University YKYoshikuni KimuraNational Kyushu Medical Center

Discussion

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Implication

Probucol may improve endothelial function in CAD; leaves open confirmation in larger trials and clinical outcome impact.

Key Points

To evaluate the effects of long-term probucol administration on endothelial function and cardiovascular biomarkers in patients with coronary artery disease.
Assessed baseline carotid intima-media thickness (IMT), flow-mediated vasodilation (FMD), cholesterol, asymmetric dimethylarginine (ADMA), and homocysteine in CAD patients (n=26) versus controls (n=12).
Administered probucol (500 mg/day, n=9) or placebo (n=9) for 3 months in CAD patients, followed by repeat measurements of FMD and serum cholesterol.
At baseline, CAD patients had significantly greater carotid IMT (p < 0.001), lower FMD (p < 0.001), and higher plasma homocysteine levels (p < 0.01) than controls, while ADMA and cholesterol were similar.
Three months of probucol significantly improved FMD in CAD patients (p < 0.05) without significantly lowering LDL-cholesterol, whereas placebo produced no change in FMD or cholesterol.

Structured PICO

Does probucol improve endothelial function in patients with coronary artery disease?

Population

38 patients total, comprising 26 patients with coronary artery disease (CAD) and 12 controls without CAD. A subset of 18 CAD patients underwent the treatment phase.

Intervention

Probucol 500 mg/day for 3 months

Comparator

Placebo for 3 months

Outcome

Endothelial function, based on flow-mediated vasodilation during reactive hyperemia (FMD)surrogate

Long-term treatment with probucol improves endothelial function in patients with coronary artery disease, an effect that appears independent of its LDL-cholesterol-lowering properties.

Cite This Study

Tagawa et al. (2004) studied this question.

synapsesocial.com/papers/6a87d0f070098fa105bb58f3 https://doi.org/10.1291/hypres.27.311

Topics

Coronary artery disease

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Long-Term Treatment with Probucol Improves Endothelial Function in Patients with Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Long-Term Treatment with Probucol Improves Endothelial Function in Patients with Coronary Artery Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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