Key result
Probucol added to lipid-lowering therapy shows no benefit over conventional therapy for major cardiovascular events.
Why the study?
Cardiovascular events have not been completely prevented by intensive statin therapy, and the effect of probucol on top of conventional lipid-lowering therapy in CHD patients was investigated.
Does probucol added to lipid-lowering therapy reduce cerebrovascular and cardiovascular events in patients with coronary heart disease and dyslipidemia?
Population
876 Japanese patients with CHD and dyslipidemia with LDL-C ≥ 140 mg/dL
Comparison
Probucol 500 mg/day added to lipid-lowering therapy vs lipid-lowering agents alone
Design
Multicenter randomized prospective study
Follow-up
More than 3 years
Authors
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May support probucol addition in CHD despite HDL-C drop; leaves open need for larger confirmatory trials.
RCT (n=831)
Open-label
1:1 dynamic allocation adjusted by LDL-C level, diabetes, and hypertension
Yes
Does probucol added to lipid-lowering therapy reduce cerebrovascular and cardiovascular events in patients with coronary heart disease and dyslipidemia?
Hazard Ratio: 0.746 (95% CI 0.471–1.182)
Absolute Event Rate: 7.8% vs 10.2%
p-value: p=0.1839
The addition of probucol to conventional lipid-lowering therapy did not significantly reduce cardiovascular events in patients with coronary heart disease.
Yamashita et al. (2020) conducted an RCT in Coronary heart disease and dyslipidemia (n=831). Probucol vs. Conventional lipid-lowering therapy alone was evaluated on Composite of cerebrovascular and cardiovascular events (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina, hospitalization for heart failure, or coronary revascularization) (HR 0.746, 95% CI 0.471-1.182, p=0.1839). Probucol added to conventional lipid-lowering therapy did not significantly reduce the composite of cerebrovascular and cardiovascular events compared to conventional therapy alone in patients with coronary heart disease (HR 0.746).
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