Why the study?
Does probucol improve the antioxidant properties of HDL in patients with heterozygous familial hypercholesterolemia?
Population
36 patients with heterozygous familial hypercholesterolemia (FH)
Comparison
Probucol vs Probucol-untreated FH patients
Design
Cross-sectional
Authors
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Probucol may enhance HDL antioxidant function in HeFH despite lower HDL-C; leaves open clinical outcome benefits in prospective trials.
Does probucol improve the antioxidant properties of HDL in patients with heterozygous familial hypercholesterolemia?
Probucol enhances HDL anti-oxidative properties, possibly through increasing PON1 activity, despite reducing HDL-C levels and particle size in patients with heterozygous familial hypercholesterolemia.
Inagaki et al. (2012) studied this question.
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