Key result
An overdose of 200 mg of escitalopram in a 22-year-old woman resulted in transient T-wave inversions in the anterior precordial leads without significant adverse cardiovascular effects.
Case Report (n=1)
No
A mild overdose of escitalopram can cause transient T-wave inversions on an ECG without significant adverse cardiovascular effects.
Transient ECG changes may occur in escitalopram overdose without major effects; this single case leaves open broader applicability to SSRI toxicity.
Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used due to their comparatively less cardiotoxic effects than tricyclic antidepressants. Corrected QT interval (QTc) prolongation is the most common electrocardiography (ECG) change that has been encountered with SSRI overdose. This case report is about a 22-year-old woman who was brought to the emergency department (ED) with an alleged history of consumption of 200 mg of escitalopram. Her ECG showed T-wave inversions in anterior leads one to five, which reverted (in leads four and five) the next day with supportive management. After 24 hours, she developed dystonia, which resolved with mild doses of benzodiazepine. Hence, ECG changes like T-wave inversions may occur even with a small overdose of an SSRI without any significant adverse effects.
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Koshy et al. (2023) conducted a case report in Escitalopram overdose (n=1). Escitalopram overdose was evaluated on Electrocardiography (ECG) changes. An overdose of 200 mg of escitalopram in a 22-year-old woman resulted in transient T-wave inversions in the anterior precordial leads without significant adverse cardiovascular effects.
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