Electrocardiographic Quantitation of Heterogeneity of Ventricular Repolarization
Key result
The PCA ratio was significantly correlated with the sum of T-wave area (R = -0.46, P < 0.001), suggesting it may more accurately reflect heterogeneity of ventricular repolarization.
Population
163 asymptomatic subjects with normal resting ECGs and normal left ventricular mass and function
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports PCA ratio for repolarization research; leaves open clinical adoption pending prospective validation.
Study Design
Type
Cross-Sectional (n=163)
Structured PICO
P
Population
163 asymptomatic subjects with normal resting ECGs and normal left ventricular mass and function.
E
Exposure
Measurement of ECG parameters including QRS onset to T-wave offset (QTod) dispersion, QRS onset to T-wave peak (QTpd) dispersion, and principal component analysis (PCA) ratio
O
Outcome
Correlation between PCA ratio, QTod, QTpd and T-wave area, amplitude, heart rate, QRS axis and duration, and QTo intervalsurrogate
Main Result
Effect estimate: R = -0.46
p-value: p=< 0.001
The PCA ratio may be a more accurate surface ECG reflection of the heterogeneity of ventricular repolarization than QT dispersion, given its independent relation to the sum of T-wave area.
Cite This Study
Okin et al. (2000) conducted a cross-sectional in Asymptomatic subjects (n=163). PCA ratio vs. QT dispersion measures was evaluated on Correlation between the sum of the T-wave area and the PCA ratio (R = -0.46, p=< 0.001). The PCA ratio was significantly correlated with the sum of T-wave area (R = -0.46, P < 0.001), suggesting it may more accurately reflect heterogeneity of ventricular repolarization.