Key result
Post-MI and LQTS show ~29 ms higher QT dispersion, while LQTS exhibits less T wave planarity.
Why the study?
The implications of the electrical cardiac vector during the repolarization phase with the genesis of QT dispersion are unknown.
Does 3-D spatial T wave loop analysis discriminate different substrates of repolarization inhomogeneity compared to conventional 12-lead ECG QT dispersion in normal subjects, post-MI patients, and LQTS patients?
Population
25 normal subjects, 30 postmyocardial infarction patients, and 17 individuals with congenital long QT syndrome
Comparison
Conventional 12-lead resting ECG QT dispersion vs spatial 3-D T wave loop morphology
Design
Cross-sectional study with simultaneous digitized standard and XYZ ECG leads
Authors
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3-D T-wave loop analysis may differentiate repolarization substrates; leaves open clinical utility beyond QT dispersion.
Cross-Sectional (n=72)
Does 3-D spatial T wave loop analysis discriminate different substrates of repolarization inhomogeneity compared to conventional 12-lead ECG QT dispersion in normal subjects, post-MI patients, and LQTS patients?
3-D spatial T wave loop morphology analysis can discriminate between different substrates of repolarization inhomogeneity (post-MI vs LQTS) that conventional scalar QT dispersion cannot.
Badilini et al. (1997) conducted a cross-sectional in Post-myocardial infarction and congenital long QT syndrome (n=72). Post-myocardial infarction and congenital long QT syndrome vs. Normal subjects was evaluated on Ventricular repolarization dispersion (RAN12o) and spatial T wave loop morphology (planarity and roundness). Post-myocardial infarction and LQTS patients showed increased QT dispersion (61.4 and 62.7 vs 33.3 ms in normals), with LQTS having greater loss of T wave loop planarity (P=0.04 vs post-MI).
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