Key result
Genetically determined higher ACE expression in male rats significantly enhanced the chronic hypertensive response after induction of renovascular hypertension (P<0.001).
Why the study?
Does genetically determined ACE expression influence the chronic hypertensive response in the rat Goldblatt model?
Population
Homozygous males of two inbred strains (F2) of Lewis x Brown-Norway (BN) rats
Comparison
Goldblatt model to induce renovascular… vs Goldblatt model in Lewis rats and sham-operated…
Design
Preclinical
Authors
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Hypothesis-generating for ACE genetics in renovascular hypertension; clinical relevance remains unproven and requires human validation.
Does genetically determined ACE expression influence the chronic hypertensive response in the rat Goldblatt model?
p-value: p=<0.001
Genetically determined ACE expression in male rats enhances the chronic hypertensive response after the induction of renovascular hypertension.
Ocaranza et al. (2002) studied Renovascular hypertension. Genetically determined higher ACE expression (BN strain) vs. Lower ACE expression (Lewis strain) was evaluated on Systolic BP (SBP) (p=<0.001). Genetically determined higher ACE expression in male rats significantly enhanced the chronic hypertensive response after induction of renovascular hypertension (P<0.001).
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