Key result
The ACE deletion/deletion and insertion/deletion genotypes were associated with a higher interlobular artery wall to lumen ratio than the insertion/insertion genotype (0.33 and 0.32 vs 0.27; P<0.05).
Why the study?
Does the ACE gene insertion/deletion polymorphism affect intrarenal microvascular structure in patients with nondiabetic renal disease?
Observational (n=56)
Does the ACE gene insertion/deletion polymorphism affect intrarenal microvascular structure in patients with nondiabetic renal disease?
Absolute Event Rate: 0.33% vs 0.27%
p-value: p=< 0.05
The ACE deletion/deletion genotype is associated with increased microvascular wall thickening in patients with nondiabetic renal disease, suggesting a genetic risk factor for vascular remodeling.
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ACE I/D polymorphism may influence renal microvascular remodeling; leaves open causal role and clinical utility of genotyping.
Teranishi et al. (1999) conducted an observational in nondiabetic renal disease (n=56). Angiotensin converting enzyme gene deletion/deletion and insertion/deletion genotypes vs. Insertion/insertion genotype was evaluated on Interlobular artery wall : lumen ratio (p=< 0.05). The ACE deletion/deletion and insertion/deletion genotypes were associated with a higher interlobular artery wall to lumen ratio than the insertion/insertion genotype (0.33 and 0.32 vs 0.27; P<0.05).
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