Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 7, 1996BMJOpen Access

Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does the deletion polymorphism of the ACE gene predict the therapeutic efficacy of captopril on the progression of diabetic nephropathy in patients with insulin dependent diabetes?

Population

35 patients with insulin dependent diabetes and nephropathy treated with captopril for a median of 7 years

Comparison

Homozygous for the deletion allele of the… vs Heterozygous or homozygous for the insertion…

Design

Cohort

Follow-up

median 7 years (range 3-9 years)

Authors

HPH.‐H. ParvingGeneral / Preventive / LipidsPJPeter Karl JacobsenElectrophysiologyLTLise TarnowHeart Failure & Transplant

Discussion

Loading...

Member takes

Implication

Homozygous ACE deletion was associated with steeper GFR decline on captopril; leaves open genotype-guided ACE inhibitor selection.

Structured PICO

Does the deletion polymorphism of the ACE gene predict the therapeutic efficacy of captopril on the progression of diabetic nephropathy in patients with insulin dependent diabetes?

P
Population
35 patients with insulin dependent diabetes and nephropathy treated with captopril for a median of 7 years (range 3-9 years)
I
Intervention
Homozygous for the deletion allele of the angiotensin converting enzyme (ACE) gene (n=11)
C
Comparator
Heterozygous or homozygous for the insertion allele of the angiotensin converting enzyme (ACE) gene (n=24)
O
Outcome
Albuminuria, arterial blood pressure, and glomerular filtration ratesurrogate

The deletion polymorphism in the ACE gene reduces the long-term beneficial effect of ACE inhibition on the progression of diabetic nephropathy in patients with insulin-dependent diabetes.

Cite This Study

Parving et al. (1996) studied this question.

synapsesocial.com/papers/6a7e0bfbc108c8d3ff0465f8https://doi.org/10.1136/bmj.313.7057.591
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of the deletion of polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy.1995 · 327 citations
  2. 2Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria.1991 · 469 citations
  3. 3Effect of Captopril on Progression to Clinical Proteinuria in Patients With Insulin-Dependent Diabetes Mellitus and Microalbuminuria1994 · 383 citations
  4. 4Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy.1988 · 330 citations
  5. 5Selection of Routine Method for Determination of Glomerular Filtration Rate in Adult Patients1976 · 267 citations