Why the study?
Does vitamin E and/or selenium prevent doxorubicin-induced delayed lethality in mice?
Population
Mice receiving a single intraperitoneal injection of doxorubicin 15 to 20 mg/kg
Design
Preclinical
Follow-up
6 months
Authors
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No efficacy against delayed lethality in mice; should not change practice and leaves open human cardioprotection trials.
Does vitamin E and/or selenium prevent doxorubicin-induced delayed lethality in mice?
Vitamin E and selenium do not provide significant long-term protection against doxorubicin-induced delayed lethality in mice.
Hermansen et al. (1986) studied this question.
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