Ventricular repolarization is correlated with metabolic control in newly diagnosed type 2 diabetes

Good metabolic control may improve cardiac function in diabetic patients. It is not known, however, whether this functional improvement is associated with concomitant electrocardiographic changes. The aim of the present prospective study was to evaluate the quantitative electrocardiographic and vectorcardiographic correlates of metabolic control, left ventricular function and dimensions, and autonomic nervous function in patients with newly diagnosed Type 2 diabetes. We studied 35 patients (20 men, 15 women; age 52 +/- 6 years (mean +/- SD) with normal electrocardiograms at 1.5 and 15 months after the diagnosis of Type 2 (non-insulin-dependent) diabetes. During the follow-up, body weight decreased, and significant improvement was observed in metabolic control, cardiac function and autonomic nervous function. Concomitantly, maximal spatial vector of T wave increased from 238 +/- 122 to 284 +/- 141 microV (P < 0.01), and this increase was correlated with a decrease in glycosylated haemoglobin A1C (r = -0.45, P < 0.01) and plasma insulin (r = -0.46, P < 0.01). In addition, duration of QRS complex shortened from 94 +/- 9 to 92 +/- 8 ms (P < 0.05), and this shortening was correlated with an increase in heart rate variability (r = -0.34; P < 0.05) and a decrease in peak early to late left ventricular filling flow velocity (r = 0.35, P < 0.05). These changes were most prominent in patients with co-existing hypertension and coronary artery disease. In conclusion, improving metabolic control of diabetes is associated with changes in ventricular repolarization and shortening of QRS complex duration.