Key result
Chlorthalidone restored blood pressure to normal in a larger percentage of patients than propranolol in both low-renin (59% vs 12%) and normal-renin (32% vs 16%) subgroups.
Why the study?
Does renin profiling help choose between chlorthalidone and propranolol to reduce blood pressure in patients with essential hypertension?
Population
54 patients with essential hypertension
Comparison
Chlorthalidone vs Propranolol (crossover design)
Design
RCT, double-blind
Authors
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Renin profiling offers limited guidance for choosing chlorthalidone over propranolol; challenges renin-based selection in essential hypertension.
RCT (n=54)
Double-blind
crossover
Does renin profiling help choose between chlorthalidone and propranolol to reduce blood pressure in patients with essential hypertension?
Renin determinations are of limited benefit in the choice of therapy between chlorthalidone and propranolol for most patients with essential hypertension.
Woods et al. (1976) conducted an RCT in essential hypertension (n=54). Chlorthalidone vs. Propranolol was evaluated on Restoration of blood pressure to normal. Chlorthalidone restored blood pressure to normal in a larger percentage of patients than propranolol in both low-renin (59% vs 12%) and normal-renin (32% vs 16%) subgroups.
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