Key result
Out-patient chlorthalidone treatment identified similar sub-groups of patients with low- or normal-renin hypertension as the inpatient sodium-restriction test, whereas frusemide did not.
Why the study?
Do out-patient renin-stimulating methods (frusemide or chlorthalidone) accurately identify low-renin hypertension compared to in-patient sodium restriction in hypertensive patients?
Population
11 normotensive control subjects and 38 hypertensive patients
Comparison
Out-patient renin-stimulating methods: frusemide… vs In-patient sodium restriction for 5 days…
Design
Cross-sectional
Follow-up
5 days (duration of test)
Authors
Loading...
May facilitate outpatient low-renin hypertension evaluation; hypothesis-generating and requires prospective validation before practice change.
Observational (n=49)
Do out-patient renin-stimulating methods (frusemide or chlorthalidone) accurately identify low-renin hypertension compared to in-patient sodium restriction in hypertensive patients?
An out-patient 5-day chlorthalidone test is a reliable alternative to in-patient sodium restriction for identifying low-renin hypertension, whereas frusemide stimulation is not.
Drayer et al. (1975) conducted an observational in Hypertension (n=49). Out-patient chlorthalidone and frusemide stimulation vs. Inpatient sodium restriction for 5 days was evaluated on Identification of low- or normal-renin hypertension. Out-patient chlorthalidone treatment identified similar sub-groups of patients with low- or normal-renin hypertension as the inpatient sodium-restriction test, whereas frusemide did not.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: