Key result
Inhibition of NHE1 with cariporide or ACE with enalapril did not prevent atrial effective refractory period abbreviation or AF inducibility caused by 7-day atrial tachypacing in dogs.
Why the study?
Does cariporide or enalapril prevent longer-term (7-day) atrial tachycardia-induced electrical remodeling in dogs?
Does cariporide or enalapril prevent longer-term (7-day) atrial tachycardia-induced electrical remodeling in dogs?
p-value: p=NS
Inhibition of NHE1 or ACE does not prevent electrical remodeling induced by 7-day atrial tachycardia in dogs, suggesting different mechanisms from short-term remodeling.
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Does not support NHE1 or ACE inhibition for long-term remodeling; leaves open distinct mechanisms from short-term atrial tachycardia models.
Kaori Shinagawa (2002) studied Atrial tachycardia-induced remodeling (n=34). Cariporide or Enalapril vs. No-drug controls and unpaced dogs was evaluated on Atrial effective refractory period (ERP) at a basic cycle length of 300 ms (p=NS). Inhibition of NHE1 with cariporide or ACE with enalapril did not prevent atrial effective refractory period abbreviation or AF inducibility caused by 7-day atrial tachypacing in dogs.
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