Key result
Insulin-dependent and non-insulin-dependent animal models of diabetes differ significantly in their cardiovascular response to ischemia, highlighting insulin as a causative factor in disease.
This review highlights significant differences in cardiovascular dysfunction and ischemic response between insulin-dependent and non-insulin-dependent animal models of diabetes.
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Animal model differences in diabetic ischemia urge caution against clinical extrapolation; leaves open insulin's causal role in human cardiovascular outcomes.
Pierce et al. (1997) conducted a review in Diabetes mellitus. Insulin-dependent diabetes vs. Non-insulin-dependent diabetes was evaluated. Insulin-dependent and non-insulin-dependent animal models of diabetes differ significantly in their cardiovascular response to ischemia, highlighting insulin as a causative factor in disease.
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