Why the study?
Does insulin administration normalize sarcolemmal Ca2+ transport defects in rats with streptozotocin-induced diabetic cardiomyopathy?
Population
Rats with chronic diabetes induced by streptozotocin (65 mg/kg iv) injection
Comparison
Insulin administration vs Untreated diabetic rats
Design
Preclinical
Authors
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Insulin may correct Ca2+ transport defects in diabetic rat hearts; leaves open relevance to human diabetic cardiomyopathy.
Does insulin administration normalize sarcolemmal Ca2+ transport defects in rats with streptozotocin-induced diabetic cardiomyopathy?
In a rat model of diabetic cardiomyopathy, defects in sarcolemmal Ca2+ transport mechanisms contribute to intracellular Ca2+ overload and are reversible with insulin treatment.
Makino et al. (1987) studied this question.
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