Population
Streptozotocin (STZ)-induced diabetic rats and isolated individual myocytes
Design
Preclinical
Authors
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Ca2+ handling defects may underlie diabetic cardiomyopathy in rats; hypothesis-generating and leaves open human translation.
Defects in intracellular Ca2+ signaling, driven by altered expression of regulatory proteins such as phospholamban and the Na+/Ca2+ exchanger, contribute to the pathogenesis of cardiomyopathy in Type 1 diabetic rats.
Choi et al. (2002) studied this question.
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