Key result
Right ventricular dysfunction affects up to ~65% of DCM patients and drives adverse outcomes.
Why the study?
Right ventricular remodeling and dysfunction negatively influence prognosis in DCM, making multimodality imaging assessment of RV involvement important for incremental prognostic and therapeutic guidance.
Does right ventricular dysfunction impact prognosis in patients with dilated cardiomyopathy?
Does right ventricular dysfunction impact prognosis in patients with dilated cardiomyopathy?
Right ventricular assessment via multimodality imaging (echocardiography and CMR) is essential in dilated cardiomyopathy as RV dysfunction provides incremental prognostic value beyond left ventricular impairment.
Dilated cardiomyopathies (DCMs) are a heterogenous group of primary myocardial diseases, representing one of the leading causes of heart failure, and the main indication for heart transplantation. While the degree of left ventricular dilation and dysfunction are two key determinants of adverse outcomes in DCM patients, right ventricular (RV) remodeling and dysfunction further negatively influence patient prognosis. Consequently, RV functional assessment and diagnosing RV involvement by using an integrative approach based on multimodality imaging is of paramount importance in the evaluation of DCM patients and provides incremental prognostic and therapeutic information. Transthoracic echocardiography remains the first-line imaging modality used for the assessment of the RV, and newer techniques such as speckle-tracking and three-dimensional echocardiography significantly improve its diagnostic and prognostic accuracy. Nonetheless, cardiac magnetic resonance (CMR) is considered the gold standard imaging modality for the evaluation of RV size and function, and all DCM patients should be evaluated by CMR at least once. Accordingly, this review provides a comprehensive overview of the anatomy and function of the RV, and the pathophysiology, diagnosis, and prognostic value of RV dysfunction in DCM patients, based on traditional and novel imaging techniques.
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Iovănescu et al. (2022) conducted a review in Dilated Cardiomyopathies. Right ventricular dysfunction vs. Preserved right ventricular function was evaluated. Right ventricular dysfunction, with an estimated prevalence of 34-65%, is a major determinant of adverse outcomes and requires systematic evaluation by multimodality imaging in patients with dilated cardiomyopathy.
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