Key result
Switching from intravenous landiolol to oral β-blockers in heart failure patients with atrial fibrillation or flutter was associated with lower 6-month all-cause mortality (HR 0.39), although this association was not independent in multivariate analysis.
Why the study?
The study was conducted to evaluate the safety and effectiveness of landiolol for treating atrial fibrillation or atrial flutter in patients with cardiac dysfunction in clinical practice in Japan.
Does switching to oral β-blockers after intravenous landiolol improve survival in patients with chronic heart failure and atrial fibrillation or atrial flutter?
Observational (n=1,121)
Yes
Does switching to oral β-blockers after intravenous landiolol improve survival in patients with chronic heart failure and atrial fibrillation or atrial flutter?
Hazard Ratio: 0.39 (95% CI 0.28–0.55)
Absolute Event Rate: 8.8% vs 21.2%
p-value: p=<0.001
In patients with chronic heart failure and tachyarrhythmia treated with intravenous landiolol, switching to oral β-blockers was associated with improved unadjusted survival, though it was not an independent predictor of mortality in multivariate analysis.
Background:The aim of the prospective post-marketing AF-CHF Landiolol Survey was to evaluate the safety and effectiveness of landiolol for the treatment of atrial fibrillation or atrial flutter in patients with cardiac dysfunction in clinical practice in Japan. This analysis reports mid-term prognoses with a focus on switching from landiolol to oral β-blockers.
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Yamashita et al. (2020) conducted an observational in Atrial fibrillation or atrial flutter with chronic heart failure (n=1,121). Switching to oral β-blockers vs. No switch to oral β-blockers was evaluated on All-cause mortality at 180 days (HR 0.39, 95% CI 0.28-0.55, p=<0.001). Switching from intravenous landiolol to oral β-blockers in heart failure patients with atrial fibrillation or flutter was associated with lower 6-month all-cause mortality (HR 0.39), although this association was not independent in multivariate analysis.
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