Key result
Treatment with enalapril normalized blood pressure and reduced muscle sympathetic-nerve activity from 35 to 23 bursts per minute in patients with chronic renal failure.
Why the study?
Does enalapril reduce muscle sympathetic-nerve activity in patients with hypertension and chronic renal failure?
Population
24 patients with hypertension, chronic renal failure, and increased plasma renin activity, along with normal…
Comparison
Enalapril (ACE inhibitor) vs Amlodipine in a separate patient group, and…
Design
Cohort
Authors
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Enalapril may lower sympathetic activity in hypertensive chronic renal failure; leaves open outcome benefit in prospective trials.
Does enalapril reduce muscle sympathetic-nerve activity in patients with hypertension and chronic renal failure?
Absolute Event Rate: 23% vs 35%
Enalapril, but not amlodipine, reduces sympathetic hyperactivity in patients with hypertension and chronic renal failure, providing a potential mechanism for the cardiovascular benefits of ACE inhibitors in this population.
Ligtenberg et al. (1999) studied Chronic renal failure and hypertension (n=24). Enalapril vs. Baseline was evaluated on Muscle sympathetic-nerve activity (bursts per minute). Treatment with enalapril normalized blood pressure and reduced muscle sympathetic-nerve activity from 35 to 23 bursts per minute in patients with chronic renal failure.
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